β-Lactamase Nomenclature

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Etymologia: β-Lactamase

Author affiliations: Justus Liebig University, Giessen, Germany (L. Falgenhauer, S.-E. Waezsada, K. Gwozdzinski, H. Ghosh, S. Doijad, C. Imirzalioglu, A. Goesmann, T. Chakraborty); German Center for Infection Research, Giessen, Germany (L. Falgenhauer, S.-E. Waezsada, K. Gwozdzinski, H. Ghosh, S. Doijad, C. Imirzalioglu, T. Chakraborty); Leibniz Institute DSMZ—German Collection of Microorganism...

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The β-lactamase inhibitor avibactam (NXL104) does not induce ampC β-lactamase in Enterobacter cloacae

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In a multicenter, multinational observational study that included neutropenic patients with bloodstream infections by extended-spectrum-β-lactamase-producing species, Gudiol et al. (Antimicrob. Agents Chemother. 61:e00164-17, 2017, https://doi.org/10.1128/AAC.00164-17) demonstrated that β-lactam/β-lactamase inhibitors are effective treatment options. A review of this work, however, reminds us t...

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Novel β-Lactamase blaARL in Staphylococcus arlettae

Whole-genome sequencing of penicillin-resistant Staphylococcus arlettae strain SAN1670 from bovine mastitis milk revealed a novel β-lactamase operon consisting of the β-lactamase-encoding gene blaARL, the antirepressor-encoding gene blaR1ARL, and the repressor-encoding gene blaIARL. The functionality of blaARL was demonstrated by gene expression in Staphylococcus aureus. The blaARL operon was c...

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Detection of β-lactamase-mediated resistance

ß-Lactams are the most widely used antibiotics, and ß-lactamases are the greatest source of resistance to them. Colorimetric tests are good, rapid, indicators of ß-lactamase production and its contingent resistance in Haemophilus, Moraxella and Neisseria spp. They can also be applied to Gram-negative bacilli but are less useful, since the usual question is not whether a ß-lactamase is produced ...

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ژورنال

عنوان ژورنال: Journal of Clinical Microbiology

سال: 2005

ISSN: 0095-1137,1098-660X

DOI: 10.1128/jcm.43.12.6220.2005